Reference descriptions of cellular electrophysiology models
نویسندگان
چکیده
UNLABELLED In recent years there has been much development of the fundamental ideas underlying mathematical model curation in regard to models of biology. While much has been achieved in the realms of systems biology and bioinformatics, little progress has been made in relation to cellular electrophysiology modeling. The primary reason for slow progress in this field is the lack of a consistent and machine-readable reference description for a given model. CellML has been widely used to describe mathematical models of cellular electrophysiology in an unambiguous, machine-readable format. Through the use of well-annotated CellML models we propose a standard by which reference descriptions of cellular electrophysiology models can be similarly defined in an unambiguous, software independent, and machine-readable format. Adoption of this standard will provide a consistent technology by which cellular electrophysiology models can be curated. AVAILABILITY http://www.bioeng.nus.edu.sg/compbiolab/p2/
منابع مشابه
Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?
Cardiac electrophysiology models have been developed for over 50years, and now include detailed descriptions of individual ion currents and sub-cellular calcium handling. It is commonly accepted that there are many uncertainties in these systems, with quantities such as ion channel kinetics or expression levels being difficult to measure or variable between samples. Until recently, the original...
متن کاملModels of cardiac tissue electrophysiology: progress, challenges and open questions.
Models of cardiac tissue electrophysiology are an important component of the Cardiac Physiome Project, which is an international effort to build biophysically based multi-scale mathematical models of the heart. Models of tissue electrophysiology can provide a bridge between electrophysiological cell models at smaller scales, and tissue mechanics, metabolism and blood flow at larger scales. This...
متن کاملA computational study of the effects of remodelled electrophysiology and mechanics on initiation of ventricular fibrillation in human heart failure
The study of pathological cardiac conditions such as arrhythmias, a major cause of mortality in heart failure, is becoming increasingly informed by computational simulation, numerically modelling the governing equations. This can provide insight where experimental work is constrained by technical limitations and/or ethical issues. It is now commonly used to provide comprehensive studies of the ...
متن کامل2018-00407 - Post-doctoral - Patient-tailored modeling of cardiac electrophysiology to understand cardiac sudden- death syndromes
The team Carmen develops mathematical models and numerical methods in order to simulate the propagation of the cardiac action potential, from the cellular scale to the scale of the body. It is part of the IHU LIRYC, the electrophysiology and heart modeling institute in Bordeaux. It collaborates actively with the clinical, imaging, cellular electrophysiology, and signal processing groups within ...
متن کامل2018-00407 - Post-doctoral - Patient-tailored modeling of cardiac electrophysiology to understand cardiac sudden- death syndromes
The team Carmen develops mathematical models and numerical methods in order to simulate the propagation of the cardiac action potential, from the cellular scale to the scale of the body. It is part of the IHU LIRYC, the electrophysiology and heart modeling institute in Bordeaux. It collaborates actively with the clinical, imaging, cellular electrophysiology, and signal processing groups within ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Bioinformatics
دوره 24 8 شماره
صفحات -
تاریخ انتشار 2008